BTN2A2 Protein (Biotin)

Produktnummer ABIN7319888

Recombinant BTN2A2-Protein exprimiert in Human Cells.

Kurzübersicht für BTN2A2 Protein (Biotin) (ABIN7319888)

Target: BTN2A2 (butyrophilin, Subfamily 2, Member A2 (BTN2A2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Reinheit: >95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses BTN2A2 Protein ist gelabelt mit Biotin.

Verwendungszweck: Recombinant Human Butyrophilin Subfamily 2 Member A2/BTN2A2 (C-Fc-Avi) Biotinylated

Sequenz: Gln33-Val237

Produktmerkmale: Biotinylated Recombinant Human Butyrophilin Subfamily 2 Member A2 is produced by our Mammalian expression system and the target gene encoding Gln33-Val237 is expressed with a Fc, Avi tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Kommentare:

55-80 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: BTN2A2 (butyrophilin, Subfamily 2, Member A2 (BTN2A2))

Andere Bezeichnung: BTN2A2

Hintergrund:

Background: Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, naive B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.

Synonym: Butyrophilin subfamily 2 member A2, BTN2A2

Molekulargewicht: 51.5 kDa

UniProt: Q8WVV5

Pathways: Activated T Cell Proliferation