ANGPTL3 Protein (Fc Tag)

Produktnummer ABIN7319869

Produktdetails

Target: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses ANGPTL3 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human Angiopoietin-related Protein 3/ANGPTL3 (C-Fc)

Sequenz: Ser17-Pro220

Produktmerkmale: Recombinant Human Angiopoietin-related Protein 3 is produced by our Mammalian expression system and the target gene encoding Ser17-Pro220 is expressed with a Fc tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Kommentare:

60-70 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, 5 % Trehalose, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Andere Bezeichnung: Angiopoietin-related protein 3 (ANGPTL3 Produkte)

Synonyme: fb60e11 Protein, fb66h02 Protein, wu:fb60e11 Protein, wu:fb66h02 Protein, zgc:111943 Protein, ANGPTL3 Protein, LOC100230785 Protein, ANG-5 Protein, ANGPT5 Protein, ANL3 Protein, FHBL2 Protein, hypl Protein, angiopoietin-like 3 Protein, angiopoietin like 3 Protein, angptl3 Protein, ANGPTL3 Protein, Angptl3 Protein

Hintergrund:

Background: Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids. ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 expression in vivo is up-regulated by LXR agonists and down-regulated by insulin, leptin, and agonists of TRβ or PPARβ.

Synonym: Angiopoietin-related protein 3, ANGPTL3, Angiopoietin-5, ANG-5, Angiopoietin-like protein 3, ANGPT5

Molekulargewicht: 50.7 kDa

UniProt: Q9Y5C1