VNN1 Protein (Fc Tag)

Produktnummer ABIN7320102

Dieses Recombinant VNN1-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für VNN1 Protein (Fc Tag) (ABIN7320102)

Target: VNN1 (Vanin 1 (VNN1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 96 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses VNN1 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Mouse VNN1/Vanin-1 Protein (Fc Tag)

Sequenz: Met 1-Ser 487

Produktmerkmale: A DNA sequence encoding the mouse VNN1 (Q9Z0K8) (Met 1-Ser 487), without the pro peptide, was fused with the Fc region of human IgG1 at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: VNN1 (Vanin 1 (VNN1))

Andere Bezeichnung: VNN1/Vanin-1

Hintergrund:

Background: Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one CN hydrolase domain. It is widely expressed with higher expression in spleen, kidney and blood. It is overexpressed in lesional psoriatic skin. Vanin-1 is also a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 Molecule was shown to be involved in the control of thymus reconstitution following sublethal irradiation.

Synonym: V-1

Molekulargewicht: 79 kDa

UniProt: Q9Z0K8

Pathways: Negative Regulation of intrinsic apoptotic Signaling