TWF1 Protein

Produktnummer ABIN7317476

Recombinant TWF1-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für TWF1 Protein (ABIN7317476)

Target: TWF1 (Twinfilin, Actin-Binding Protein 1 (TWF1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 94 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human TWF1/Twinfilin-1 Protein

Sequenz: Met 1-Asp 252

Produktmerkmale: A DNA sequence encoding the human TWF1 isoform 4 (Q12792-4) (Met 1-Asp 252) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: TWF1 (Twinfilin, Actin-Binding Protein 1 (TWF1))

Andere Bezeichnung: TWF1/Twinfilin-1

Hintergrund:

Background: Twinfilin-1; also known as Protein A6; Protein tyrosine kinase 9; TWF1 and PTK9; is a cytoplasm protein which belongs to the actin-binding proteins ADF family and Twinfilin subfamily. Twinfilin-1 (TWF1 / PTK9 ) is a highly conserved actin monomer-binding protein that regulates cytoskeletal dynamics in organisms from yeast to mammals. In addition to the mammalian twinfilin-1; a second protein with approximately 65% sequence identity to twinfilin-1 exists in mouse and humans. TWF1 / PTK9 is expressed at high levels in the colon; testis; ovary; prostate and lung. It is expressed at lower levels in the brain; bladder and heart. It is not detected in liver. TWF1 / PTK9 is an actin-binding protein involved in motile and morphological processes. It inhibits actin polymerization; likely by sequestering G-actin. By capping the barbed ends of filaments; it also regulates motility. TWF1 / PTK9 seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.

Synonym: A6;MGC23788;MGC41876;PTK9

Molekulargewicht: 29 kDa

Pathways: Regulation of Actin Filament Polymerization, Maintenance of Protein Location