TGFB3 Protein

Produktnummer ABIN7319107

Dieses Recombinant TGFB3-Protein wird in Human Cells produziert.

Kurzübersicht für TGFB3 Protein (ABIN7319107)

Target: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human TGFB3 Protein (Active)

Sequenz: Ala301-Ser412(Tyr340Phe)

Produktmerkmale: Recombinant Human/Mouse Transforming Growth Factor beta 3 is produced by our Mammalian expressionsystem and the target gene encoding Ala301-Ser412(Tyr340Phe) is expressed.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells.  The ED50 for this effect is 10-80 pg/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 4 mM HCl.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Andere Bezeichnung: TGFB3

Hintergrund:

Background: Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.

Synonym: Transforming growth factor beta-3,TGFB3,TGF-beta-3,Latency-associated peptide,LAP

Molekulargewicht: 12.7 kDa

UniProt: P10600

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus