TCN2 Protein (His tag)

Produktnummer ABIN7317824

Dieses Recombinant TCN2-Protein wird in CHO Cells produziert.

Kurzübersicht für TCN2 Protein (His tag) (ABIN7317824)

Target: TCN2 (Transcobalamin II (TCN2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: CHO Cells

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses TCN2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human TCN2 Protein (His Tag)

Sequenz: Met 1-Trp 427

Produktmerkmale: A DNA sequence encoding the human TCN2 (NP_000346.2) (Met 1-Trp 427) was expressed with a C-terminal polyhistidine tag.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: TCN2 (Transcobalamin II (TCN2))

Andere Bezeichnung: TCN2

Hintergrund: D22S676,D22S750,TC-2,TC2,TCII,Transcobalamin-II,Transcobalamin II, also known as TCN2 and TC II, is a plasma protein that binds cobalamin (Cbl, vitamin B12) as it is absorbed in the terminal ileum and distributes to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. Transcobalamin II is a non-glycolated secretory protein of molecular mass 43 kDa. Its plasma membrane receptor (TC II-R) is a heavily glycosylated protein with a monomeric molecular mass of 62 kDa. Human TCN2 gene is composed of nine exons and eight introns spanning approximately 20 kb with multiple potential transcription start sites. A number of genetic abnormalities are characterized either by a failure to express TCN2 or by synthesis of an abnormal protein. The TCN2 deficiency results in cellular cobalamin deficiency, an early onset of megaloblastic anaemia, and neurological abnormalities.

Molekulargewicht:

Calculated MW: 46.7 kDa

Observed MW: 44 kDa

Gen-ID: 6948

NCBI Accession: NP_000346

UniProt: P20062