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TLK2 Protein

This anti-TLK2 antibody (ABIN7317071) is a Baculovirus infected Insect Cells antibody detecting TLK2 in . Suitable for Human.
Produktnummer ABIN7317071

Kurzübersicht für TLK2 Protein (ABIN7317071)

Target

Alle TLK2 Proteine anzeigen
TLK2 (Tousled-Like Kinase 2 (TLK2))

Protein-Typ

Recombinant

Spezies

  • 5
  • 2
Human

Quelle

  • 3
  • 2
  • 1
  • 1
Baculovirus infected Insect Cells

Reinheit

> 95 % as determined by reducing SDS-PAGE.
  • Verwendungszweck

    Recombinant Human TLK2/PKU-ALPHA Protein

    Sequenz

    Leu 397-Asn772

    Produktmerkmale

    A DNA sequence encoding the human TLK2 (Q86UE8-1) (Leu397-Asn772) was fused with two additional amino acids (Gly & Pro) at the N-terminus.

    Endotoxin-Niveau

    < 1.0 EU per μg as determined by the LAL method.
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    Produkt
    Expressionssystem
    Konjugat
    Origin
    Preis ab
    Expressionssystem HEK-293 Cells
    Konjugat His tag
    Origin Human
    Preis ab 13.711,36 €
    Expressionssystem Cell-free protein synthesis (CFPS)
    Konjugat Strep Tag
    Origin Human
    Preis ab 20.480,57 €

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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Frozen, Liquid

    Buffer

    Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 8.0

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target

    TLK2 (Tousled-Like Kinase 2 (TLK2))

    Andere Bezeichnung

    TLK2/PKU-ALPHA

    Hintergrund

    Background: Serine / threonine-protein kinase tousled-like 2; also known as PKU-alpha; Tousled-like kinase 2 and TLK2; is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair; DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta; liver; kidney; pancreas; heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.

    Synonym: HsHPK;PKU-ALPHA

    Molekulargewicht

    43.6 kDa
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