TLK2 Protein (His-GST)

Produktnummer ABIN7317072

Dieses Recombinant TLK2-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für TLK2 Protein (His-GST) (ABIN7317072)

Target: TLK2 (Tousled-Like Kinase 2 (TLK2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses TLK2 Protein ist gelabelt mit His-GST.

Verwendungszweck: Recombinant Human TLK2/PKU-ALPHA Protein (His&GST Tag)

Sequenz: Leu 397-Asn 772

Produktmerkmale: A DNA sequence encoding the amino acids (Leu 397-Asn 772) of human TLK2 (Q86UE8-1) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 0.5 mM PMSF, pH 8.0

Konservierungsmittel: PMSF

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: TLK2 (Tousled-Like Kinase 2 (TLK2))

Andere Bezeichnung: TLK2/PKU-ALPHA

Hintergrund: HsHPK,PKU-ALPHA,Serine / threonine-protein kinase tousled-like 2, also known as PKU-alpha, Tousled-like kinase 2 and TLK2, is a nucleus protein which belongs to theprotein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair, DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains oneprotein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.

Molekulargewicht:

Calculated MW: 71.3 kDa

Observed MW: 65 kDa

Gen-ID: 11011

UniProt: Q86UE8