TIMP1 Protein

Produktnummer ABIN7320662

Dieses Recombinant TIMP1-Protein wird in Human Cells exprimiert.

Kurzübersicht für TIMP1 Protein (ABIN7320662)

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Reinheit: > 95 % as determined by SDS-PAGE

Produktdetails

Verwendungszweck: Recombinant Mouse TIMP1/TIMP Protein

Sequenz: Cys25-Arg205

Produktmerkmale: Recombinant Mouse Tissue Inhibitors of Metalloproteinases 1 is produced by our Mammalian expression system and the target gene encoding Cys25-Arg205 is expressed.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Andere Bezeichnung: TIMP1/TIMP

Hintergrund:

Background: Mouse Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) is a member of TIMP family. The homologous proteins of TIMPs regulate the activity of matrix metalloproteinases (MMPs), including inhibition of active MMPs, proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Timp-1 complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. It also mediates erythropoiesis in vitro, but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. It is known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16, without MMP-14.

Synonym: Metalloproteinase Inhibitor 1, Erythroid-Potentiating Activity, EPA, Fibroblast collagenase Inhibitor, Collagenase Inhibitor, Tissue Inhibitor of Metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP

Molekulargewicht: 20.2 kDa

UniProt: P12032