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Thymic Stromal Lymphopoietin Protein (TSLP)

Dieses Recombinant Thymic Stromal Lymphopoietin-Protein wird in Escherichia coli (E. coli) produziert.
Produktnummer ABIN7319083

Kurzübersicht für Thymic Stromal Lymphopoietin Protein (TSLP) (ABIN7319083)

Target

Alle Thymic Stromal Lymphopoietin (TSLP) Proteine anzeigen
Thymic Stromal Lymphopoietin (TSLP)

Protein-Typ

Recombinant

Spezies

  • 25
  • 10
  • 5
  • 3
Human

Quelle

  • 19
  • 15
  • 4
  • 2
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 90 % as determined by reducing SDS-PAGE.
  • Verwendungszweck

    Recombinant Human TSLP Protein

    Sequenz

    Tyr29-Gln159

    Produktmerkmale

    Recombinant Human Thymic stromal lymphopoietin is produced by our E.coli expression system and the target gene encoding Tyr29-Gln159 is expressed.

    Endotoxin-Niveau

    < 1.0 EU per μg as determined by the LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

    Lagerung

    4 °C,-20 °C,-80 °C

    Informationen zur Lagerung

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    Thymic Stromal Lymphopoietin (TSLP)

    Andere Bezeichnung

    TSLP

    Hintergrund

    Background: Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral mucosa, skin and in salivary glands. In aa sequence level, Human TSLP displays about 43 % identity with mouse TSLP.TSLP is a cytokine that functions mainly on myeloid cells, it induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells.TSLP has proliferative effects on the myeloid cell line and may initiate asthma or atopic dermatitis responses by directly activating mast cells . TSLP signals cells via the interleukin-7 receptor-α chain (IL-7Rα),shared with IL-7, together with the TSLP receptor (TSLPR) subunit. Recent studies indicate that TSLP and its receptor are novel therapeutic targets for rheumatoid arthritis,for increased intraarticular TSLP concentrations in patients has caused chemotaxis and activation of arthritogenic T cells.

    Synonym: Thymic stromal lymphopoietin,TSLP

    Molekulargewicht

    15.1 kDa

    UniProt

    Q969D9
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