Tspan-8 Protein (His tag)

Produktnummer ABIN7198214

Recombinant Tspan-8-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für Tspan-8 Protein (His tag) (ABIN7198214)

Target: Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: (87.8+10.7) % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Tspan-8 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human TSPAN8/Tetraspanin 8 Protein (His Tag)

Sequenz: Lys110-Asn205

Produktmerkmale: A DNA sequence encoding the human TSPAN8 (P19075) (Lys110-Asn205) was expressed with an N-terminal polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))

Andere Bezeichnung: TSPAN8/Tetraspanin 8

Hintergrund:

Background: Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a negative regulator of Tspan8 expression. p53 as a regulator of melanoma invasion and the concept that reactivating p53 could provide a strategy for modulating not only proliferative but also invasive capacity in melanoma treatment. Tetraspanin 8 (TSPAN8) is a tumor-associated antigen implicated in tumor progression and metastasis. TSPAN8 may play an important role in mCRC cell invasion. TSPAN8 was overexpressed in human gastric cancer tissues and gastric cancer cell lines compared with the normal. TSPAN8 overexpression promoted cell proliferation and invasion, while TSPAN8 suppression inhibited cell proliferation and invasion. TSPAN8 could activate the ERK MAPK pathway in gastric cancer cells, and MEK-ERK inhibition reversed the effects of TSPAN8 overexpression on cell proliferation and invasion.

Synonym: CO-029,TM4SF3

Molekulargewicht: 13.4 kDa

UniProt: P19075