TSPAN1 Protein (Fc Tag)

Produktnummer ABIN7317314

Recombinant TSPAN1-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für TSPAN1 Protein (Fc Tag) (ABIN7317314)

Target: TSPAN1 (Tetraspanin 1 (TSPAN1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses TSPAN1 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human TSPAN1 Protein (aa 110-211, Fc Tag)

Sequenz: Tyr110-Asn211

Produktmerkmale: A DNA sequence encoding the human TSPAN1 (O60635)(Tyr110-Asn211) was expressed with the Fc region of rabbit IgG at the N-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: TSPAN1 (Tetraspanin 1 (TSPAN1))

Andere Bezeichnung: TSPAN1

Hintergrund:

Background: TSPAN1 belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins have four hydrophobic domains, intracellular N- and C-termini and two extracellular domains. Tetraspanins act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane. They also mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN1 interacts with human thiamine transporter-1 (hTHTR-1). HTHTR-1 contributes to intestinal thiamine uptake, and its function is regulated at both the transcriptional and posttranscriptional levels. TSPAN1 and hTHTR-1 colocalize in human intestinal epithelial HuTu-80 cells. Coexpression of TSPAN1 in these cells led to a significant decrease in the rate of degradation of hTHTR-1 compared with cells expressing the hTHTR-1 alone, in fact the half-life of the TSPAN1 protein was twice longer in the former cell type compared with the latter cell type.

Synonym: NET1,TM4C,TM4SF,TSPAN1

Molekulargewicht: 39.1 kDa

UniProt: O60635