STUB1 Protein
Kurzübersicht für STUB1 Protein (ABIN7318418)
Target
Alle STUB1 Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
-
-
Verwendungszweck
- Recombinant Human STUB1 Protein
-
Sequenz
- Met 1-Tyr303
-
Produktmerkmale
- Recombinant Human E3 Ubiquitin-Protein Ligase CHIP is produced by our E.coli expression system and the target gene encoding Met1-Tyr303 is expressed.
-
Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
-
-
Möchten Sie weitere Optionen für dieses Protein ?
!Entdecken Sie unsere vordefinierten maßgeschneiderten Proteine und Proteinservices!ProduktExpressionssystemKonjugatOriginPreis abExpressionssystem HEK-293 CellsKonjugat His tagOrigin HumanPreis ab 13.711,36 €Expressionssystem Cell-free protein synthesis (CFPS)Konjugat Strep TagOrigin HumanPreis ab 20.480,57 €Ihr Projekt erfordert weitere Anpassungen? Kontaktieren Sie uns und entdecken Sie unsere maßgeschneiderten Proteinlösungen
-
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-304) protein (His tag)
custom-made STUB1 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)custom-made STUB1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)STUB1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (GST tag)STUB1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) protein (Myc-DYKDDDDK Tag)STUB1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Frozen, Liquid
-
Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
-
- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
-
Andere Bezeichnung
- STUB1
-
Hintergrund
-
Background: E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
Synonym: E3 Ubiquitin-Protein Ligase CHIP, Antigen NY-CO-7, CLL-Associated Antigen KW-8, Carboxy Terminus of Hsp70-Interacting Protein, STIP1 Homology and U Box-Containing Protein 1, STUB1, CHIP
-
Molekulargewicht
- 34.9 kDa
-
UniProt
- Q9UNE7
-
Pathways
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
Target
-
