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s100a4 Protein

Dieses Recombinant s100a4-Protein wird in HEK-293 Cells exprimiert.
Produktnummer ABIN7197760

Kurzübersicht für s100a4 Protein (ABIN7197760)

Target

Alle s100a4 (S100A4) Proteine anzeigen
s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

Protein-Typ

Recombinant

Spezies

  • 13
  • 4
  • 3
  • 3
  • 1
Maus

Quelle

  • 15
  • 4
  • 3
  • 1
HEK-293 Cells

Reinheit

> 85 % as determined by SDS-PAGE
  • Verwendungszweck

    Recombinant Mouse S100A4 Protein

    Sequenz

    Ala2-Lys101

    Produktmerkmale

    A DNA sequence encoding the mouse S100A4 (P07091)(Ala2-Lys101) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.

    Endotoxin-Niveau

    < 1.0 EU per μg of the protein as determined by the LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from sterile PBS, pH 7.4

    Lagerung

    4 °C,-20 °C,-80 °C

    Informationen zur Lagerung

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

    Andere Bezeichnung

    S100A4

    Hintergrund

    Background: S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin β, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S100A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.

    Synonym: 18A2,42a,Capl,FSp1,metastasin,Mts1,PeL98,pk9a

    Molekulargewicht

    11.7 kDa

    UniProt

    P07091

    Pathways

    S100 Proteine
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