S100A12 Protein

Produktnummer ABIN7317645

Dieses Recombinant S100A12-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für S100A12 Protein (ABIN7317645)

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: ELISA

Reinheit: > 98 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human S100A12/CAGC Protein

Sequenz: Met 1-Glu 92

Produktmerkmale: A DNA sequence encoding the native human S100A12 (NP_005612.1) (Met 1-Glu 92) was expressed.

Sterilität: 0.2 μm filtered

Biological Activity Comment: Immobilized recombinant human S100A12 at 2 μg/ml (100 μl/well) can bind human AGER with a linear range of 0.032-20 μg/ml.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Andere Bezeichnung: S100A12/CAGC

Hintergrund: CGRP,Calcitermin,Calcium-binding protein in amniotic fluid 1,Calgranulin-C,EN-RAGE,Extracellular newly identified RAGE-binding protein,MRP-6,Migration inhibitory factor-related protein 6,Protein S100-A12,S100 calcium-binding protein A12,S100A12,S100 proteinis a family of low molecular weight protein found in vertebrates characterized by twoEF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is100 % soluble in ammonium sulfateat neutral pH . Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. S100A12 plays an important role in the inflammatory response.

Molekulargewicht:

Calculated MW: 10.6 kDa

Observed MW: 10 kDa

Gen-ID: 6283

NCBI Accession: NP_005612

UniProt: P80511

Pathways: Toll-Like Receptors Cascades, S100 Proteine