Podoplanin Protein (PDPN) (His tag)

Produktnummer ABIN7320345

Recombinant Podoplanin-Protein exprimiert in Baculovirus infected Insect Cells.

Kurzübersicht für Podoplanin Protein (PDPN) (His tag) (ABIN7320345)

Target: Podoplanin (PDPN)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Baculovirus infected Insect Cells

Reinheit: > 92 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses Podoplanin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Podoplanin/PDPN Protein (His Tag)

Sequenz: Met 1-Lys 133

Produktmerkmale: A DNA sequence encoding the mouse PDPN N-terminal fragment (NP_034459.2) (Met 1-Lys 133) was expressed,with a C-terminal polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Podoplanin (PDPN)

Andere Bezeichnung: Podoplanin/PDPN

Hintergrund:

Background: Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: Gp38;OTS-8;RANDAM-2;T1-alpha;T1a;T1alpha;Podoplanin; Aggrus; Glycoprotein 38; PA2.26 antigen

Molekulargewicht: 13 kDa

NCBI Accession: NP_034459

Pathways: Dicarboxylic Acid Transport