PDE9A Protein (His tag)

Produktnummer ABIN7317497

Recombinant PDE9A-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für PDE9A Protein (His tag) (ABIN7317497)

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses PDE9A Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human PDE9A Protein (His Tag)

Sequenz: Pro 181-Lys 506

Produktmerkmale: A DNA sequence encoding the human PDE9A (O76083-2) C-terminal segment (Pro 181-Lys 506) was expressed, with a polyhistide tag at the N-terminus.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Andere Bezeichnung: PDE9A

Hintergrund:

Background: High affinity cGMP-specific 3';5'-cyclic phosphodiesterase 9A; also known as PDE9A; is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis; brain; small intestine; skeletal muscle; heart; lung; thymus; spleen; placenta; kidney; liver; pancreas; ovary and prostate) except blood. Highest levels of PDE9A is in brain; heart; kidney; spleen; prostate and colon. Isoform PDE9A12 is found in prostate. PDE9A mRNA is widely distributed throughout the rat and mouse brain; with the highest expression observed in cerebellar Purkinje cells. PDE9A is the only cGMP-specific PDE with significant expression in the forebrain; and as such is likely to play an important role in NO-cGMP signaling. PDE9A is highly conserved between species and is widely distributed throughout the rodent brain. PDE9A is probably involved in maintenance of low cGMP levels in cells and might play an important role in a variety of brain functions involving cGMP-mediated signal transduction. PDE9A hydrolyzes the second messenger cGMP; which is a key regulator of many important physiological processes. PDE9A represents a novel drug target worthy of further study.

Synonym: HSPDE9A2

Molekulargewicht: 40 kDa