Peroxiredoxin 1 Protein (PRDX1) (His tag)

Produktnummer ABIN7318889

Recombinant Peroxiredoxin 1-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für Peroxiredoxin 1 Protein (PRDX1) (His tag) (ABIN7318889)

Target: Peroxiredoxin 1 (PRDX1)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Peroxiredoxin 1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Peroxiredoxin 1/PRDX1 Protein (His Tag)

Sequenz: Met 1-Lys199

Produktmerkmale: Recombinant Human Peroxiredoxin-1 is produced by our E.coli expression system and the target gene encoding Met1-Lys199 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, 10 % glycerol, 0.1 mM DTT, pH 6.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: Peroxiredoxin 1 (PRDX1)

Andere Bezeichnung: Peroxiredoxin 1/PRDX1

Hintergrund:

Background: Peroxiredoxin-1(PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8(+) T-cells and have a proliferative effect in cancer development or progression.

Synonym: Peroxiredoxin-1,Natural killer cell-enhancing factor A,NKEF-A,Proliferation-associated gene protein,PAG,Thioredoxin peroxidase 2,Thioredoxin-dependent peroxide reductase 2,PAGA, PAGB, TDPX2,MSP23,NKEF-A,NKEFA,PAG,PRX1,PRXI,TDPX2

Molekulargewicht: 25.3 kDa

UniProt: Q06830

Pathways: p53 Signalweg, EGFR Signaling Pathway, CXCR4-mediated Signaling Events