Osteomodulin Protein (OMD) (His tag)

Produktnummer ABIN7320274

Dieses Recombinant Osteomodulin-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für Osteomodulin Protein (OMD) (His tag) (ABIN7320274)

Target: Osteomodulin (OMD)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 96 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses Osteomodulin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Osteomodulin/OMD Protein (His Tag)

Sequenz: Met 1-Ile 423

Produktmerkmale: A DNA sequence encoding the mouse OMD (NP_036180.1) (Met 1-Ile 423) precusor was expressed, with a C-terminal polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Osteomodulin (OMD)

Andere Bezeichnung: Osteomodulin/OMD

Hintergrund:

Background: Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein which belongs to the small leucine-rich proteoglycan (SLRP) family and Class II subfamily. SLRP family proteins are normally found in extracellular matrices, but Osteomodulin is the only member restricted to mineralized tissues. Osteomodulin is primarily expressed by osteoblasts and might have a role in regulation of mineralization. In bone OSAD has been localized in primary spongiosa within the bovine fetal rib growth plate. Moreover, in situ hybridization has shown expression of OSAD in osteoblasts close to the cartilage and bone border in the growth plate of rat femur. OSAD may play an important role during tooth development and biomineralization of dentin. Osteomodulin is a cell binding keratan sulfate proteoglycan which was recently isolated from mineralized bovine bone and subsequently cloned and sequenced. Osteomodulin may be implicated in biomineralization processes. It has a function in binding of osteoblasts via the alpha (V) beta (3)-integrin. It is likely that Osteomodulin is an osteoblast maturation marker that is induced by osteoclast activity. Osteomodulin is also an early marker for terminally differentiated matrix producing osteoblasts.

Synonym: OSAD,SLRR2C

Molekulargewicht: 48.8 kDa

NCBI Accession: NP_036180

Pathways: Glycosaminoglycan Metabolic Process