NINJ1 Protein (Fc Tag)

Produktnummer ABIN7321087

Produktdetails

Target: NINJ1 (Ninjurin 1 (NINJ1))

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NINJ1 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Rat Ninjurin-1/NINJ1 Protein (Fc Tag)

Sequenz: Met 1-Pro 79

Produktmerkmale: A DNA sequence encoding the rat NINJ1 (P70617) extracellular domain (Met 1-Pro 79) was fused with the Fc region of human IgG1 at the N-terminus.

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: NINJ1 (Ninjurin 1 (NINJ1))

Andere Bezeichnung: Ninjurin-1/NINJ1 (NINJ1 Produkte)

Synonyme: nin1 Protein, MGC79511 Protein, ninjurin Protein, NIN1 Protein, NINJURIN Protein, AU024536 Protein, ninjurin 1 Protein, ninjurin 1 L homeolog Protein, NINJ1 Protein, ninj1 Protein, ninj1.L Protein, Ninj1 Protein

Hintergrund:

Background: Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19(+) CD10(+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia cells. Ninjurin-1 is expressed also in a number of other adult and embryonic tissues, predominantly in epithelial cells. Its expression is upregulated after axotomy in neurons and in Schwann cells surrounding the distal nerve segment. Upregulated expression of ninjurin-1 has been identified as a marker of minimal residual disease in B-lineage acute lymphoblastic leukemia. It mediates homophilic adhesion, and promotes neurite extension of dorsal root ganglion neurons in vitro. Ninjurin-1 has been found to show a high expression level in the liver tissue of patients with hepatocellular carcinoma, and this seems to be associated with cases of cirrhosis and chronic viral hepatitis. It has been reported that NINJURIN increases p21 expression and induces cellular senescence in human hepatoma cells.

Synonym: NINJ1

Molekulargewicht: 37 kDa

UniProt: P70617