Kurzübersicht für NFASC Protein (Fc Tag) (ABIN7197149)
Target
Alle NFASC Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Aufreinigungstag / Konjugat
- Dieses NFASC Protein ist gelabelt mit Fc Tag.
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Verwendungszweck
- Recombinant Human NFASC/Neurofascin protein (Fc Tag)
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Sequenz
- Met 1-Gln939
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Produktmerkmale
- A DNA sequence encoding the human NFASC (XP_011507630.1) (Met1-Gln939) was expressed with the Fc region of human IgG1 at the C-terminus.
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Sterilität
- 0.2 μm filtered
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Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Neurofascin (NFASC) (AA 1239-1347) protein (His tag)
NFASC Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
Neurofascin (NFASC) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)NFASC Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Neurofascin (NFASC) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)NFASC Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Lagerung
- 4 °C,-20 °C,-80 °C
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Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Haltbarkeit
- 12 months
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- NFASC (Neurofascin (NFASC))
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Andere Bezeichnung
- NFASC/Neurofascin
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Hintergrund
- NF,NRCAML,NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.
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Molekulargewicht
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Calculated MW: 130 kDa
Observed MW: 130 kDa
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Gen-ID
- 23114
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NCBI Accession
- NP_001005388
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UniProt
- O94856
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Pathways
- Cell-Cell Junction Organization
Target
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