NRN1 Protein (His tag)

Produktnummer ABIN7317340

Dieses Recombinant NRN1-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für NRN1 Protein (His tag) (ABIN7317340)

Target: NRN1 (Neuritin 1 (NRN1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses NRN1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Neuritin/NRN1 Protein (Baculovirus, His Tag)

Sequenz: Met 1-Asn 115

Produktmerkmale: A DNA sequence encoding the mature form of human NRN1 (Q9NPD7) (Met 1-Asn 115) was fused with a polyhistidine tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: NRN1 (Neuritin 1 (NRN1))

Andere Bezeichnung: Neuritin/NRN1

Hintergrund:

Background: Neuritin 1 (NRN1) is a member of neuritin family. Neuritin is a glycosylphosphatidylinositol- anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF) and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. Thus, neuritin is considered as a downstream effector of activity-induced neurite outgrowth. In clinical, neuritin levels in diabetes were reduced in both dorsal root ganglia and sciatic nerve of rats, and these deficits were reversed in vivo by treatment with NGF. This manipulation of neuritin levels in diabetes may provide a potential target for the therapeutic intervention in the management of neuropathy.

Synonym: dJ380B8.2,MGC44811,NRN

UniProt: Q9NPD7