Myeloperoxidase Protein (MPO) (His tag)

Produktnummer ABIN7320799

Dieses Recombinant Myeloperoxidase-Protein wird in Human Cells exprimiert.

Kurzübersicht für Myeloperoxidase Protein (MPO) (His tag) (ABIN7320799)

Target: Myeloperoxidase (MPO)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Myeloperoxidase Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Myeloperoxidase/MPO Protein (His Tag)

Sequenz: Met16-Thr718

Produktmerkmale: Recombinant Mouse Myeloperoxidase is produced by our Mammalian expression system and the target gene encoding Met16-Thr718 is expressed with a 10His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Myeloperoxidase (MPO)

Andere Bezeichnung: Myeloperoxidase/MPO

Hintergrund:

Background: Myeloperoxidase (MPO) is a hemecontaining enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxidedependent conversion of chloride, bromide, and iodide to multiple reactive species. MPO activity results in protein nitrosylation and the formation of 3-chlorotyrosine and dityrosine crosslinks. Modification of ApoB100, as well as the lipid and cholesterol components of LDL and HDL, promotes the development of atherosclerosis. MPO is also associated with a variety of other diseases, and inhibits vasodilation in inflammation by depleting the levels of NO. Serum albumin functions as a carrier protein during MPO movement to the basolateral side of epithelial cells. MPO is stored in neutrophil azurophilic granules. Upon cellular activation, it is deposited into pathogencontaining phagosomes. While mice lacking MPO are impaired in clearing select microbial infections,MPO deficiency in humans does not necessarily result in heightened susceptibility to infections.

Synonym: Myeloperoxidase, MPO

Molekulargewicht: 81.1 kDa

UniProt: P11247

Pathways: Chromatin Binding