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Layilin Protein (LAYN) (Fc Tag)

Recombinant Layilin-Protein exprimiert in HEK-293 Cells.
Produktnummer ABIN7317963

Kurzübersicht für Layilin Protein (LAYN) (Fc Tag) (ABIN7317963)

Target

Alle Layilin (LAYN) Proteine anzeigen
Layilin (LAYN)

Protein-Typ

Recombinant

Spezies

  • 9
  • 3
  • 1
  • 1
Human

Quelle

  • 6
  • 3
  • 3
  • 1
  • 1
HEK-293 Cells

Reinheit

> 90 % as determined by reducing SDS-PAGE.
  • Aufreinigungstag / Konjugat

    Dieses Layilin Protein ist gelabelt mit Fc Tag.

    Verwendungszweck

    Recombinant Human Layilin/LAYN Protein (Fc Tag)

    Sequenz

    Met 1-Glu 220

    Produktmerkmale

    A DNA sequence encoding the extracellular domain (Met 1-Glu 220) of human Layilin (NP_849156.1) precursor was expressed with the C-terminal fused Fc region of human IgG1.

    Endotoxin-Niveau

    < 1.0 EU per μg as determined by the LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5

    Lagerung

    4 °C,-20 °C,-80 °C

    Informationen zur Lagerung

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    Layilin (LAYN)

    Andere Bezeichnung

    Layilin/LAYN

    Hintergrund

    Background: Layilin, a recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions between the actin filaments and the cell membrane by binding to integral membrane proteins and to the cytoskeleton. Layilin is a newly identified membrane-binding site for talin in peripheral ruffles of spreading cells, a ten-amino acid motif in the layilin cytoplasmic domain is sufficient for talin binding, and its adjacent LH2-LH3 tandem arrays in the cytoplasmic domain provide docking sites for talin. Furthermore, talin binds layilin, PIPK1gamma and integrins in similar although subtly different ways. Layilin binds specifically to hyaluronan (HA) through its extracellular domain, a ubiquitous extracellular matrix component in most animal tissues and body fluids, but not to other tested glycosaminoglycans. The research suggests that layilin may mediate signals from extracellular matrix to the cell cytoskeleton via interaction with different intracellular binding partners and thereby be involved in the modulation of cortical structures in the cell. All the above actions reveal an interesting parallel between layilin and the known HA receptor CD44. In addition, merlin and radixin have been identified as different intracellular binding partners of layilin. Accordingly, it has been suggested that layilin plays roles in a variety of cellular processes, including cell shape, adhesion, motility, and homeostasis, as well as signal transduction. In addition, layilin might play an important role in the process of invasion and lymphatic metastasis of lung carcinoma.

    Synonym: Layilin

    Molekulargewicht

    49.5 kDa

    NCBI Accession

    NP_849156
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