Latexin Protein (LXN) (His tag)

Produktnummer ABIN7196736

Dieses Recombinant Latexin-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für Latexin Protein (LXN) (His tag) (ABIN7196736)

Target: Latexin (LXN)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Latexin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Latexin/LXN Protein (His Tag)

Sequenz: Glu 2-Glu222

Produktmerkmale: A DNA sequence encoding the human Latexin (NP_064554.3) (Glu 2-Glu222) was expressed, fused with a polyhistidine tag at the N-terminus.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM HEPES, 0.1M KCl, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Latexin (LXN)

Andere Bezeichnung: Latexin/LXN

Hintergrund:

Background: Latexin; also known as endogenous carboxypeptidase inhibitor; tissue carboxypeptidase inhibitor; TCI; ECI and LXN; is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart; prostate; ovary; kidney; pancreas; and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart; prostate; ovary; kidney; pancreas; and colon; but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets; and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors; Latexin is related to a human putative tumor suppressor protein; TIG1. In addition; Latexin is also implicated in Alzheimer's disease.

Synonym: ECI;TCI

Molekulargewicht: 26.8 kDa

NCBI Accession: NP_064554