CDH6 Protein (His tag)

Produktnummer ABIN7320085

Dieses Recombinant CDH6-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CDH6 Protein (His tag) (ABIN7320085)

Target: CDH6 (K-Cadherin (CDH6))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 90 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses CDH6 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Cadherin-6/CDH6 Protein (His Tag)

Sequenz: Met1-Ala615

Produktmerkmale: A DNA sequence encoding the mouse CDH6 (P97326) (Met1-Ala615) was expressed with a C-terminal polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CDH6 (K-Cadherin (CDH6))

Andere Bezeichnung: Cadherin-6/CDH6

Hintergrund:

Background: Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Cadherin-6 (CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa. Additionally, it is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. Thus , Cadherin-6 is a new prognostic factor for renal cancer.

Synonym: cad6,cadherin-6,K-cadherin

Molekulargewicht: 68.7 kDa

UniProt: P97326

Pathways: Cell-Cell Junction Organization