JAG1 Protein (Fc Tag)

Produktnummer ABIN7319310

Dieses Recombinant JAG1-Protein wird in Human Cells exprimiert.

Kurzübersicht für JAG1 Protein (Fc Tag) (ABIN7319310)

Target: JAG1 (Jagged 1 (JAG1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses JAG1 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human Jagged 1/JAG1 Protein (Fc Tag)

Sequenz: Gln34-Ser1046

Produktmerkmale: Recombinant Human jagged-1 is produced by our Mammalian expression system and the target gene encoding Gln34-Ser1046 is expressed with a Fc tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: JAG1 (Jagged 1 (JAG1))

Andere Bezeichnung: Jagged 1/JAG1

Hintergrund:

Background: Protein jagged-1 I, also known as Jagged-1, JAGL1, HJ1, JAG1 and CD339, is a single-pass type I membrane protein. JAG1 contains one DSL domain and sixteen EGF-like domain. JAG1 acts as a ligand for multiple Notch receptors and is involved in the mediation of Notch signaling. JAG1 may participate in early and late stages of mammalian cardiovascular development, JAG1 inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1 are the cause of Alagille syndrome type 1, which is autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations.

Synonym: Protein jagged-1 I, Jagged-1, JAGL1, HJ1, JAG1 and CD339,AGS,AHD,AWS,Jagged 1

Molekulargewicht: 138.5 kDa

NCBI Accession: NP_000205

Pathways: Notch Signalweg, Stem Cell Maintenance