IL-17 Protein

Produktnummer ABIN7320461

Dieses Recombinant IL-17-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für IL-17 Protein (ABIN7320461)

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Reinheit: > 97 % as determined by SDS-PAGE

Produktdetails

Verwendungszweck: Recombinant Mouse Interleukin-17/IL-17 Protein (Active)

Sequenz: Thr 22-Ala158

Produktmerkmale: A DNA sequence encoding the mature form of mouse IL17a (Q62386) (Thr 22-Ala158) was expressed and purified.

Biological Activity Comment: 1. Measured by its binding ability in a functional ELISA. 2. Immobilized recombinant mouse IL17a at 10 μg/mL (100 μl/well) can bind human IL17Ra-Fc2h with a linear range of 16-500 ng/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Andere Bezeichnung: Interleukin-17/IL-17

Hintergrund:

Background: IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Synonym: Ctla-8,Ctla8,IL-17,IL-17A,Il17

Molekulargewicht: 15.5 kDa

UniProt: Q62386