IL1RL1 Protein

Produktnummer ABIN7318037

Recombinant IL1RL1-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für IL1RL1 Protein (ABIN7318037)

Target: IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human IL1RL1/ST2 Protein

Sequenz: Met 1-Phe 328

Produktmerkmale: The secreted isoform of human IL1RL1 (NP_003847.2) (Met 1-Phe 328) with five amino acids (DDDDK) at the C-terminus was expressed and purified.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

Andere Bezeichnung: IL1RL1/ST2

Hintergrund:

Background: IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

Synonym: DER4;FIT-1;IL1RL1;IL33R;IL-1 R4;ST2;ST2L;ST2V;T1

Molekulargewicht: 35.6 kDa

NCBI Accession: NP_003847