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HOXB4 Protein (His tag)

Dieses Recombinant HOXB4-Protein wird in Escherichia coli (E. coli) exprimiert.
Produktnummer ABIN7319405

Kurzübersicht für HOXB4 Protein (His tag) (ABIN7319405)

Target

Alle HOXB4 Proteine anzeigen
HOXB4 (Homeobox B4 (HOXB4))

Protein-Typ

Recombinant

Spezies

  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 5
  • 2
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 95 % as determined by SDS-PAGE
  • Aufreinigungstag / Konjugat

    Dieses HOXB4 Protein ist gelabelt mit His tag.

    Verwendungszweck

    Recombinant Human HOXB4 Protein (His Tag)

    Sequenz

    Met1-Leu251

    Produktmerkmale

    Recombinant Human Homeobox protein B4 is produced by our E.coli expression system and the target gene encoding Met1-Leu251 is expressed with a 6His tag at the N-terminus.

    Endotoxin-Niveau

    < 1.0 EU per μg as determined by the LAL method.
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    Produkt
    Expressionssystem
    Konjugat
    Origin
    Preis ab
    Expressionssystem HEK-293 Cells
    Konjugat His tag
    Origin Human
    Preis ab 13.711,36 €

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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Frozen, Liquid

    Buffer

    Supplied as a 0.2 μm filtered solution of 4 mM HCl.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target

    HOXB4 (Homeobox B4 (HOXB4))

    Andere Bezeichnung

    HOXB4

    Hintergrund

    Background: Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

    Synonym: Homeobox protein Hox-B4, Homeobox protein Hox-2.6, Homeobox protein Hox-2F, HOXB4, HOX2F

    Molekulargewicht

    29.8 kDa

    UniProt

    P17483
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