Histone Cluster 2 H4 Family Member a (HIST2H4A) Protein

Produktnummer ABIN7317723

Dieses Recombinant -Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für Histone Cluster 2 H4 Family Member a (HIST2H4A) Protein (ABIN7317723)

Target: Histone Cluster 2 H4 Family Member a (HIST2H4A)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human Histone H4/HIST2H4A Protein

Sequenz: Met 1-Gly103

Produktmerkmale: A DNA sequence encoding the human Histone H4 (NP_003539.1) (Met1-Gly103) was expressed.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 2 mM β-ME in dd H2O, pH 6.0

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Histone Cluster 2 H4 Family Member a (HIST2H4A)

Andere Bezeichnung: Histone H4/HIST2H4A

Hintergrund:

Background: Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells.

Synonym: FO108,H4,H4/A,H4/B,H4/C,H4/D,H4/E,H4/G,H4/H,H4/J,H4/K,H4/M,H4/N,H4F2,H4FA,H4FB,H4FC,H4FD,H4FE,H4FG,H4FH,H4FI,H4FJ,H4FK,H4FM,H4FN,HIST1H4A,HIST1H4B H4/I,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4,HIST2H4A

Molekulargewicht: 11.4 kDa

NCBI Accession: NP_003539