HSPB11 Protein (His tag)

Produktnummer ABIN7318561

Produktdetails

Target: HSPB11 (Heat Shock Protein Family B (Small), Member 11 (HSPB11))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses HSPB11 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human HSPB11 Protein (His Tag)

Sequenz: Met 1-Ser144

Produktmerkmale: Recombinant Human Heat Shock Protein beta-11 is produced by our E.coli expression system and the target gene encoding Met1-Ser144 is expressed with a 6His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 100 mM NaCl, 2 mM DTT, 10 % Glycerol, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: HSPB11 (Heat Shock Protein Family B (Small), Member 11 (HSPB11))

Andere Bezeichnung: HSPB11 (HSPB11 Produkte)

Synonyme: C1orf41 Protein, HSPCO34 Protein, IFT25 Protein, PP25 Protein, 2900042B11Rik Protein, cb02d06 Protein, mg:cb02d06 Protein, heat shock protein family B (small), member 11 Protein, heat shock protein family B (small) member 11 Protein, heat shock protein, alpha-crystallin-related, b11 Protein, Hspb11 Protein, HSPB11 Protein, hspb11 Protein

Hintergrund:

Background: Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected against etoposide-induced cell death that correlated with a decreased release of mitochondrial Cytochrome C into the cytosol. Inhibition of HSP90 function completely abrogated the protective effect of HSPB11. This data suggests that at least in the case of HSPB11, interaction with other chaperone machines besides HSPA1A may contribute to functional specificity and cellular functioning.

Synonym: Heat Shock Protein Beta-11, Hspb11, Placental Protein 25, PP25, HSPB11, C1orf41

Molekulargewicht: 18.5 kDa

UniProt: Q9Y547