GAMT Protein (His tag)

Produktnummer ABIN7318555

Dieses Recombinant GAMT-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für GAMT Protein (His tag) (ABIN7318555)

Target: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses GAMT Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human GAMT Protein (His Tag)

Sequenz: Met 1-Gly236

Produktmerkmale: Recombinant Human Guanidinoacetate N-methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Gly236 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,1 mMDTT, pH 8.0 .

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Andere Bezeichnung: GAMT

Hintergrund:

Background: GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.

Synonym: Guanidinoacetate N-methyltransferase, GAMT, PIG2,TP53I2

Molekulargewicht: 29.5 kDa

UniProt: Q14353