QPCT Protein (His tag)

Produktnummer ABIN7195939

Dieses Recombinant QPCT-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für QPCT Protein (His tag) (ABIN7195939)

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses QPCT Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Glutaminyl cyclase/QPCT Protein (His Tag)

Sequenz: Ala33-Leu361

Produktmerkmale: A DNA sequence encoding the human QPCT (Q16769-1) (Ala33-Leu361) was fused with a polyhistide tag at the N-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Andere Bezeichnung: Glutaminyl cyclase/QPCT

Hintergrund:

Background: Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate(pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioactive peptides, while the aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases. Glutaminyl cyclase's structure reveals an alpha/beta scaffold akin to that of two-zinc exopeptidases but with several insertions and deletions, particularly in the active-site region. Glutaminyl cyclase's amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. It is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides.

Synonym: GCT,QC,sQC

Molekulargewicht: 39.7 kDa