ECM1 Protein (His tag)

Produktnummer ABIN7320312

Dieses Recombinant ECM1-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für ECM1 Protein (His tag) (ABIN7320312)

Target: ECM1 (Extracellular Matrix Protein 1 (ECM1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 88 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses ECM1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse ECM1 Protein (His Tag)(Active)

Sequenz: Met 1-Glu 559

Produktmerkmale: A DNA sequence encoding the mouse ECM1 isoform 1 (Q61508-1) (Met 1-Glu 559) was expressed, fused with a polyhistidine tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind human MMP-9 in a functional ELISA.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ECM1 (Extracellular Matrix Protein 1 (ECM1))

Andere Bezeichnung: ECM1

Hintergrund:

Background: Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein and playing a pivotal role in endochondral bone formation, angiogenesis, and tumour biology. Three splice variants have been identified: ECM1a (540 aa) is most widely expressed, with highest expression in the placenta and heart; ECM1b (415 aa) is differentiation-dependent expressed and found only in tonsil and associated with suprabasal keratinocytes; ECM1c (559 aa) accounts for approximately 15% of skin ECM1. Although ECM1 is not tumor specific, is significantly elevated in many malignant epithelial tumors and is suggested as a possible trigger for angiogenesis, tumor progression and malignancies. It also has been shown to regulate endochondral bone formation, skeletal development and tissue remodeling. 

Synonym: AI663821;p85

Molekulargewicht: 62.5 kDa