Endoglin Protein (ENG) (His tag)

Produktnummer ABIN7318004

Recombinant Endoglin-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für Endoglin Protein (ENG) (His tag) (ABIN7318004)

Target: Endoglin (ENG)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Endoglin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Endoglin/CD105 Protein (His Tag)

Sequenz: Met 1-Gly 586

Produktmerkmale: A DNA sequence encoding the extracellular domain of human CD105 (NP_001108225.1) (Met 1-Gly 586) was expressed, with C-terminal fused polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Endoglin (ENG)

Andere Bezeichnung: Endoglin/CD105

Hintergrund:

Background: Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

Synonym: Endoglin; END; CD105; ENG;HHT1;ORW1

Molekulargewicht: 62.3 kDa

NCBI Accession: NP_001108225