DPP10 Protein (His tag)

Produktnummer ABIN7317488

Recombinant DPP10-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für DPP10 Protein (His tag) (ABIN7317488)

Target: DPP10 (Dipeptidylpeptidase 10 (DPP10))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses DPP10 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human DPP10/DPRP3 Protein (His Tag)

Sequenz: Leu 56-Glu 796

Produktmerkmale: A DNA sequence encoding the human DPP10 isoform 1 (Q8N608-1) extracellular domain (Leu 56-Glu 796) was expressed, with a polyhistidine tag at the N-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: DPP10 (Dipeptidylpeptidase 10 (DPP10))

Andere Bezeichnung: DPP10/DPRP3

Hintergrund:

Background: Inactive dipeptidyl peptidase 10, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP10, is a single-pass type I I membrane protein which belongs to the peptidase S9B family. DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP10 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Genetic variations in DPP10 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.

Synonym: DPL2;DPPY;DPRP-3;DPRP3

Molekulargewicht: 87.4 kDa