DPP7 Protein (His tag)

Produktnummer ABIN7195431

Dieses Recombinant DPP7-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für DPP7 Protein (His tag) (ABIN7195431)

Target: DPP7 (Dipeptidyl-Peptidase 7 (DPP7))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 98 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses DPP7 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human DPP7/DPPII/DPP2 Protein (His Tag)

Sequenz: Met 1-Leu 492

Produktmerkmale: A DNA sequence encoding the human DPPII (NP_037511.2) (Met 1-Leu 492) with a C-terminal polyhistidine tag was expressed.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: DPP7 (Dipeptidyl-Peptidase 7 (DPP7))

Andere Bezeichnung: DPP7/DPPII/DPP2

Hintergrund:

Background: DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.

Synonym: DPP2,DPPII,QPP

Molekulargewicht: 53.6 kDa

NCBI Accession: NP_037511