CNDP2 Protein (His tag)

Produktnummer ABIN7320351

Produktdetails

Target: CNDP2 (CNDP Dipeptidase 2 (Metallopeptidase M20 Family) (CNDP2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses CNDP2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse CNDP2/CPGL/PEPA Protein (His Tag)(Active)

Sequenz: Met 1-Asn 475

Produktmerkmale: A DNA sequence encoding the mouse CNDP2 (NP_075638.2) (Met 1-Asn 475) was expressed, with a C-terminal polyhistidine tag.

Reinheit: > 97 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to cleave carnosine (β-Ala-His) in a two step assay (mouse CNDP2 concentration 10 μg/ml). The specific activity is >40 pmoles/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 10 % glycerol, pH 8.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CNDP2 (CNDP Dipeptidase 2 (Metallopeptidase M20 Family) (CNDP2))

Andere Bezeichnung: CNDP2/CPGL/PEPA (CNDP2 Produkte)

Synonyme: 0610010E05Rik Protein, C76600 Protein, Cn2 Protein, Dip-2 Protein, Pep-1 Protein, Pep1 Protein, CN2 Protein, CPGL Protein, HsT2298 Protein, PEPA Protein, cn2 Protein, cpgl Protein, darmin-r Protein, CNDP2 Protein, zgc:92569 Protein, wu:fd20d11 Protein, wu:fe17f09 Protein, cndp2b Protein, PEPC1 Protein, PEPCase Protein, PPC1 Protein, PPEPC4 Protein, pepc Protein, carnosine dipeptidase 2 Protein, CNDP dipeptidase 2 (metallopeptidase M20 family) Protein, CNDP dipeptidase 2 (metallopeptidase M20 family) S homeolog Protein, CNDP dipeptidase 2 (metallopeptidase M20 family) L homeolog Protein, phosphoenolpyruvate carboxylase 1 Protein, Cndp2 Protein, CNDP2 Protein, cndp2 Protein, cndp2.S Protein, cndp2.L Protein, pep1 Protein

Hintergrund:

Background: Cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. It may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform 1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.

Synonym: CNDP2;CNDP dipeptidase 2;Cytosolic non-specific dipeptidase;Glutamate carboxypeptidase-like protein 1;Dip-2;Pep-1;Pep1

Molekulargewicht: 54 kDa

NCBI Accession: NP_075638