CD69 Protein (CD69) (Fc Tag,ECD)

Produktnummer ABIN7320166

Recombinant CD69-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für CD69 Protein (CD69) (Fc Tag,ECD) (ABIN7320166)

Target: CD69

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 90 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD69 Protein ist gelabelt mit Fc Tag,ECD.

Verwendungszweck: Recombinant Mouse CD69 Protein (Fc tag, ECD)

Sequenz: Gly64-Arg199

Produktmerkmale: A DNA sequence encoding the mouse Cd69 (NP_001028294.1) (Gly64-Arg199) was expressed with the Fc region of human IgG1 at the N-terminus.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD69

Andere Bezeichnung: CD69

Hintergrund:

Background: Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.

Synonym: 5830438K24Rik,AI452015,AIM,VEA,CLEC2C

Molekulargewicht: 44.1 kDa

NCBI Accession: NP_001028294