CD59a Protein (CD59A) (His tag)

Produktnummer ABIN7320173

Dieses Recombinant CD59a-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CD59a Protein (CD59A) (His tag) (ABIN7320173)

Target: CD59a (CD59A)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 92 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD59a Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse CD59a/MAC-IP Protein (His Tag)

Sequenz: Met 1-Lys 95

Produktmerkmale: A DNA sequence encoding the mouse CD59a (O55186) (Met 1-Lys 95), without the pro peptide, was fused with a C-terminal polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD59a (CD59A)

Andere Bezeichnung: CD59a/MAC-IP

Hintergrund:

Background: Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins.It was found that the CD59/Protectin antigen is a small protein sometimes associated with larger components (45 and 80 kD) in urine. CD59/Protectin antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor, it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria.

Synonym: AA987121,Cd59,protectin,RP24-297H17.1

Molekulargewicht: 9.7 kDa

UniProt: O55186