CD38 Protein (His tag)

Produktnummer ABIN7194833

Recombinant CD38-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für CD38 Protein (His tag) (ABIN7194833)

Target: CD38

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 97 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD38 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse CD38 Protein (His Tag)(Active)

Sequenz: Leu 45-Thr 304

Produktmerkmale: A DNA sequence encoding the extracellular domain of mouse CD38 (NP_031672.2) (Leu 45-Thr 304) was expressed, fused with a C-terminal polyhistidine tag.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to convert the substrate nicotinamide guanine dinucleotide (NGD+) to cyclic GDPribose. The specific activity is >50,000pmols/min/ug.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM MES, 0.15M NaCl, pH 6.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD38

Hintergrund:

Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.

Synonym: cADPr hydrolase 1, CD38 antigen (p45), CD38 antigen, CD38 Molecule, CD38, Cyclic ADP-ribose hydrolase 1, Cyclic ADP-ribose Hydrolase, EC 3.2.2.5, NAD(+) nucleosidase, T10,ADPRC 1-rs1,ADPRC1,Cd38,Cd38-rs1,I-19

Molekulargewicht: 31.3 kDa

NCBI Accession: NP_031672