DC-SIGN/CD209 Protein (AA 59-404) (Fc Tag)

Produktnummer ABIN7319880

Dieses Recombinant DC-SIGN/CD209-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für DC-SIGN/CD209 Protein (AA 59-404) (Fc Tag) (ABIN7319880)

Target: DC-SIGN/CD209 (CD209) (CD209)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 59-404

Aufreinigungstag / Konjugat: Dieses DC-SIGN/CD209 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human DC-SIGN/CD209 (N-Fc)

Sequenz: Gln59-Ala404

Produktmerkmale: Recombinant Human CD209 Antigen is produced by our Mammalian expression system and the target gene encoding Gln59-Ala404 is expressed with a Fc tag at the N-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: DC-SIGN/CD209 (CD209) (CD209)

Andere Bezeichnung: DC-SIGN/CD209

Hintergrund: CD209,CD209 Antigen,CD209 Molecule,CDSIGNHIV gpl20-binding protein,CLEC4L,DC-SIGN,DC-SIGN1,DCSIGN,CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. The DC-SIGN/CD209 lectin domain binds mannose oligosaccharides on pathogens including HIV as well as self glycoproteins including ICAMs (2, 4). DC-SIGN/CD209 binds to butyrophilin 2A1 and this interaction can be blocked by HIV pp120. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors.

Molekulargewicht:

Calculated MW: 65.3 kDa

Observed MW: 75 kDa

Gen-ID: 30835

UniProt: Q9NNX6