CD1b Protein (CD1B) (Fc Tag)

Produktnummer ABIN7317475

Recombinant CD1b-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für CD1b Protein (CD1B) (Fc Tag) (ABIN7317475)

Target: CD1b (CD1B)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 88 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD1b Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human CD1B/CD1A Protein (Fc Tag)

Sequenz: Met 1-Ser 303

Produktmerkmale: A DNA sequence encoding the human CD1B (NP_001755) (Met1-Ser 303) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: CD1b (CD1B)

Andere Bezeichnung: CD1B/CD1A

Hintergrund: CD1,CD1A,CD1B,R1,CD1B contains 1 Ig-like (immunoglobulin-like) domain and belongs to the CD1 family. CD1 family members are transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. During protein synthesis and maturation, they bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. CD1B localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.. It is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1B is an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Molekulargewicht:

Calculated MW: 58.6 kDa

Observed MW: 59-69 kDa

Gen-ID: 910

NCBI Accession: NP_001755

UniProt: P29016