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CD1b Protein (CD1B) (Fc Tag)

This anti-CD1b antibody (ABIN7317475) is a HEK-293 Cells antibody detecting CD1b in . Suitable for Human.
Produktnummer ABIN7317475

Kurzübersicht für CD1b Protein (CD1B) (Fc Tag) (ABIN7317475)

Target

Alle CD1b (CD1B) Proteine anzeigen
CD1b (CD1B)

Protein-Typ

Recombinant

Spezies

  • 7
  • 1
Human

Quelle

  • 3
  • 2
  • 1
  • 1
  • 1
HEK-293 Cells

Reinheit

> 88 % as determined by reducing SDS-PAGE.
  • Aufreinigungstag / Konjugat

    Dieses CD1b Protein ist gelabelt mit Fc Tag.

    Verwendungszweck

    Recombinant Human CD1B/CD1A Protein (Fc Tag)

    Sequenz

    Met 1-Ser 303

    Produktmerkmale

    A DNA sequence encoding the human CD1B (NP_001755) (Met1-Ser 303) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

    Endotoxin-Niveau

    < 1.0 EU per μg as determined by the LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from sterile PBS, pH 7.4

    Lagerung

    4 °C,-20 °C,-80 °C

    Informationen zur Lagerung

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    CD1b (CD1B)

    Andere Bezeichnung

    CD1B/CD1A

    Hintergrund

    Background: CD1B contains 1 Ig-like (immunoglobulin-like) domain and belongs to the CD1 family. CD1 family members are transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. During protein synthesis and maturation, they bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. CD1B localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.. It is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1B is an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

    Synonym: CD1,CD1A,CD1B,R1

    Molekulargewicht

    58.6 kDa

    NCBI Accession

    NP_001755
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