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CD180 Protein (Fc Tag)

Recombinant CD180-Protein exprimiert in HEK-293 Cells.
Produktnummer ABIN7320259

Kurzübersicht für CD180 Protein (Fc Tag) (ABIN7320259)

Target

Alle CD180 Proteine anzeigen
CD180 (CD180 Molecule (CD180))

Protein-Typ

Recombinant

Spezies

  • 2
  • 2
Maus

Quelle

  • 3
  • 1
HEK-293 Cells

Reinheit

> 90 % as determined by SDS-PAGE
  • Aufreinigungstag / Konjugat

    Dieses CD180 Protein ist gelabelt mit Fc Tag.

    Verwendungszweck

    Recombinant Mouse CD180/RP105/LY64 Protein (Fc Tag)

    Sequenz

    Met 1-Ser 626

    Produktmerkmale

    A DNA sequence encoding the mouse CD180 (NP_032559.2) extracellular domain (Met 1-Ser 626) was fused with the Fc region of human IgG1 at the C-terminus.

    Endotoxin-Niveau

    < 1.0 EU per μg of the protein as determined by the LAL method.
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from sterile PBS, pH 7.4

    Lagerung

    4 °C,-20 °C,-80 °C

    Informationen zur Lagerung

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    CD180 (CD180 Molecule (CD180))

    Andere Bezeichnung

    CD180/RP105/LY64

    Hintergrund

    Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180 / RP105 interact with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86. CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS.

    Synonym: F630107B15,Ly78,RP105

    Molekulargewicht

    95 kDa

    NCBI Accession

    NP_032559

    Pathways

    Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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