CD16 Protein (CD16) (His tag)

Produktnummer ABIN7320834

Dieses Recombinant CD16-Protein wird in Human Cells produziert.

Kurzübersicht für CD16 Protein (CD16) (His tag) (ABIN7320834)

Target: CD16

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD16 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse CD16/FCGR3 Protein (His Tag)

Sequenz: Leu32-Thr215

Produktmerkmale: Recombinant Mouse CD16 is produced by our Mammalian expression system and the target gene encoding Leu32-Thr215 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD16

Andere Bezeichnung: CD16/FCGR3

Hintergrund:

Background: Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like domains consisting of immunoglobulin domain, repeat, signa and transmembrane, transmembrane helix. It is expressed on a variety of myeloid and lymphoid cells and associates with Fc R gamma to deliver an activating signal upon ligand binding. Fcgr3 is IgG binding and activation or inhibition of immune responses such as antibody-dependent cellular cytotoxicity, phagocytosis, cell surface receptor signaling pathway and positive regulation of type I/IIa/III hypersensitivity.

Synonym: Low affinity immunoglobulin gamma Fc region receptor III, Fcgr3, Fc gamma Receptor III, CD-antigen 16, CD16, FcRIII, IgG Fc receptor III

Molekulargewicht: 21.9 kDa

UniProt: Q5D5I8

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process