CES2 Protein (His tag)

Produktnummer ABIN7194592

Dieses Recombinant CES2-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CES2 Protein (His tag) (ABIN7194592)

Target: CES2 (Carboxylesterase 2 (CES2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 85 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses CES2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Carboxylesterase-2/CES2 Protein (His Tag)(Active)

Sequenz: Met 1-Lys 557

Produktmerkmale: A DNA sequence encoding the extracellular domain of mouse CES2 (NP_663578.1) (Met 1-Lys 557) was expressed, with a polyhistidine tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to hydrolyze pnitrophenylacetate. The specific activity is >90,000 pmoles/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CES2 (Carboxylesterase 2 (CES2))

Andere Bezeichnung: Carboxylesterase-2/CES2

Hintergrund:

Background: Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.

Synonym: ces2A3

Molekulargewicht: 60.4 kDa

NCBI Accession: NP_663578