CES1 Protein (His tag)

Produktnummer ABIN7318241

Dieses Recombinant CES1-Protein wird in Human Cells produziert.

Kurzübersicht für CES1 Protein (His tag) (ABIN7318241)

Target: CES1 (Carboxylesterase 1 (CES1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CES1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Carboxylesterase 1/CES1 Protein (His Tag)

Sequenz: His19-Glu562

Produktmerkmale: Recombinant Human Carboxylesterase 1 is produced by our Mammalian expression system and the target gene encoding His19-Glu562 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: CES1 (Carboxylesterase 1 (CES1))

Andere Bezeichnung: Carboxylesterase 1/CES1

Hintergrund:

Background: Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. These enzymes have broad substrate specificity ranging from small molecule esters such as phenylester to long chain fatty acid esters and thioesters. They are major determinants of the pharmacokinetic behavior of most therapeutic agents containing an ester or amide bond. CES1 shares the serine hydrolase fold observed in other esterases. CES1 hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. CES1 participates in detoxification of drugs such as cocaine and heroin in serum and liver. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.

Synonym: Liver Carboxylesterase 1, Acyl-Coenzyme A:Cholesterol Acyltransferase, ACAT, Brain Carboxylesterase hBr1, Carboxylesterase 1, CE-1, hCE-1, Cocaine Carboxylesterase, Egasyn, HMSE, Methylumbelliferyl-Acetate Deacetylase 1, Monocyte/Macrophage Serine Esterase, Retinyl Ester Hydrolase, REH, Serine Esterase 1, Triacylglycerol Hydrolase, TGH, CES1, CES2, SES1

Molekulargewicht: 61.1 kDa

Pathways: Monocarboxylic Acid Catabolic Process