Cadherin 8 Protein (CDH8) (AA 1-621)

Produktnummer ABIN7194516

Dieses Recombinant Cadherin 8-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für Cadherin 8 Protein (CDH8) (AA 1-621) (ABIN7194516)

Target: Cadherin 8 (CDH8)

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: HEK-293 Cells

Reinheit: > 80 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 1-621

Verwendungszweck: Recombinant Rat Cadherin-8/CDH8 Protein

Sequenz: Met1-Met621

Produktmerkmale: A DNA sequence encoding the rat CDH8 (NP_445845.2)(Met1-Met621) was expressed with six amino acids (LEVLFQ) at the C-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Cadherin 8 (CDH8)

Andere Bezeichnung: Cadherin-8/CDH8

Hintergrund: CDH8,Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin 8, also known as CDH 8, is a type II classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type Itransmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98 % homology.

Molekulargewicht:

Calculated MW: 65.9 kDa

Observed MW: 76-85 kDa

NCBI Accession: NP_445845

UniProt: A0A8I6AFP6

Pathways: Cell-Cell Junction Organization